Dr. Huaiyu Yang Curriculum Vitae - Imperial College London


Dr. Huaiyu Yang Chemical Engineering Department, Loughborough University, LE11 3UE, UK, Mobile: +44 (0) 770 9686 684 E-mail: [email protected], Personal web: http://www.lboro.ac.uk/departments/chemical/staff/huaiyu-yang/

My research interest is to develop new generation of bioseparation technology for biopharmaceuticals with applications of nano-technology and gas-liquid-solid interactions, and create continuous manufacturing platform from fermentation broth to bioproducts. I have initiated some research programs and collaborations with academics and industrials, and my researches are in wide range from small organic molecules to big biomolecules, from fundamental nucleation theory to pharmaceutical industrial projects, and from molecular interactions to scaling up and continuous crystallisation. Employment 2018-

Lecturer in Chemical Engineering, Chemical Engineering Department, Loughborough University, Loughborough, UK


Research Associate, on biopharmaceutical separation and protein crystallization, Department of Chemical Engineering, Imperial College London, London, UK


Research Associate, on continuous crystallization processing and pharmaceuticals crystallization, EPSRC center of Continuous Manufacturing and Crystallization, Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, Glasgow, UK Visiting scientist, on continuous crystallization process development, GSK, Stevenage, UK

Education 2008–2013

Ph.D in Chemical Engineering, Royal Institute of Technology (KTH), Sweden


BSc, MEng in Chemical Engineering, Tianjin University, China

Funding and Academic awards 2012-2013 2009-2011 2009-2013

Lars hiertas Minne small early career research grant at KTH Bjöns travel grant at KTH, Linders travel grant at KTH IKF Scholarship at KTH

Professional developments and memberships Fellowship of the Higher Education Academy; PGCert in Advanced Academic Studies. Reviewer of 10+ journals: Crystal Growth and Design, Crystengcomm, Chemical Engineering Research and Design, International Journal of Pharmaceutics, and etc Evidence of Esteem 2016-2017 2016-2017 2009–2013

Administrations: Laboratory safety officer, coordinates or provides training on occupational health and safety requirements Outreach: Hot-ice crystallization experiment demonstrations and popular scientific presentations in a primary school in London Leadership: President of Chinese Students and Scholars Association (300+ member), organization of academic multidiscipline seminars and activities (1000+ audience) at KTH

Industrial experiences and research projects Research Project Responsibility: • Investigate the mechanism of the reaction, crystallization and polymorph transition process • Communicate, exchange knowledge and engage with students, colleagues, business and


other agencies • Assess and characterize key pharmaceutical products • Lead or work as a team to deliver the robust and consistent methodology for continuous crystallization 2016-2018

Nano-template seeding and bio-separation of protein by continuous crystallization (EPSRC and Horizon 2020). • Synthesis of 3D-nano silica templates and functionalized with various pore sizes and particle sizes, and functionalizing the surface of templates by different function groups • Biocrystallization with nano-template seeding, membrane, platform design, optimization of bio-separation conditions


6 Industrial crystallization projects (confidential) well delivered to GSK and AstraZeneca • Determining phase diagram and control oiling out and spherical crystallization • Test and optimize the parameters of mixing time, mixing method, reaction time, residence time and crystal growth rate to choose the right continuous crystallization platform and obtain the right polymorph and good size distribution products. • Visiting scientist at GSK, Stevenage, UK, 7 months. Lead research and development initiatives on (continuous) crystallization processing ad scaling up.


Visiting researcher at Limerick University, Ireland, 3 months • Crystallization in liquid-liquid phase separation solution, processes control and design

Publications Papers 1. Yang, H.; Peczulis P., Inguva P., Li X.; Heng, J.*, (2018) Continuous Protein Crystallisation Platform and Process: Case of Lysozyme, Engineering Research and Development (in press) 2. Yang, H.; Zhang F. Wu, H.;*(2018) Review on Life Cycle of Parabens: Synthesis, Degradation, Characterization and Safety Analysis, Current Organic Chemistry 22, 769-779. 3. Yang, H.; Song C.; Lim Y.; Chen, W.; Heng, J.*, (2017) Selective Crystallisation of Carbamazepine Polymorphs on Differing Surface Properties, CrystEngComm 19, 6573-6578 (Front Cover Article) 4. Yang, H.*; Florence, A.; (2017) Relating induction time and metastable zone width, CrystEngComm 19, 3966-3978 5. Yang, H.; Yu, X. ; Raval, V. ; Makkawi, Y.; Florence, A.*; (2016) The effect of oscillatory flow on nucleation kinetics of butyl paraben. Crystal Growth & Design 16, 875-886. 6. Bhardwaj, R.; Yang, H.; Florence, A.*; (2016) Crystal structure of the co-crystal butylparaben– isonicotinamide (1/1)." Acta Crystallographica Section E: Crystallographic Communications 72, 53-55. 7. Yang, H.*; (2015) Relation between Metastable Zone Width and Induction Time of Butyl Paraben in Ethanol. CrystEngComm 17, 577-586. 8. Yang, H.*; Rasmuson, Å., (2015) Phase equilibrium and mechanisms of crystallization in liquid-liquid phase separating system. Fluid Phase Equilibria 385, 120-128. 9. Yang, H.*, (2015) Reply to the "Comment on 'Relation between metastable zone width and induction time of butyl paraben in ethanol'" by L.-D. Shiau,. CrystEngComm. 17, 4405-4407. 10. Yang, H.; Michael, S.; Jacek Z.; Rasmuson, Å.*, (2014) Influence of solvent and solid-state structure on nucleation of parabens. Crystal Growth & Design 14, 3890-3902. 11. Yang, H.; Chen H.; Rasmuson, Å.*, (2014) Sandwich crystals of butyl paraben. CrystEngComm 16, 88638873. 12. Yang, H.*; Rasmuson, Å., (2014) Ternary phase diagrams of ethyl paraben and propyl paraben in ethanol aqueous solvents. Fluid Phase Equilibria 376, 69-75. 13. Yang, H.; Rasmuson, Å.*, (2013) Nucleation of butyl paraben in different solvents. Crystal Growth & Design 13, 4226-4238. 14. Yang, H.; Rasmuson, Å.*, (2012) Investigation of batch cooling crystallization in a Liquid–Liquid separating system by PAT. Organic Process Research & Development 16, 1212-1224


Yang, H.; Thati, J.; Rasmuson, Å.*, (2012) Thermodynamics of molecular solids in organic solvents. The Journal of Chemical Thermodynamic 48, 150-159. 16. Yang, H.; Rasmuson, Å.*, (2010) Solubility of butyl paraben in methanol, ethanol, propanol, ethyl acetate, acetone, and acetonitrile. Journal of Chemical & Engineering Data 55, 5091-5093. 17. Dang, L.; Yang, H.; Black S.; Wei H.*; (2009) The effect of temperature and solvent composition on transformation of β-to α-Glycine as monitored in situ by FBRM and PVM. Organic Process Research & Development 13, 1301-1306. Book Chapter 18. Yang, H.; H. ter Horst, J.*, (2017) Crystal Nucleation of Small Organic Molecules in New Perspectives on Mineral Nucleation and Growth, Springer, ISBN: 978-3-319-45667-6 19. Yang, H.; Chen, W.; Heng, J.*, (2018) Continuous Protein Crystallisation, RSC, (Invited and submitted) Teaching and mentoring Experiences 15.


Lecturer in Reaction Engineering for third year undergraduate students in Loughborough University Lectured “Bioseperation and crystallization” for undergraduate students (80) at Imperial College London Co-Supervised 12 MSci and undergraduate students at Strathclyde University and Imperial College London Lab tutorial and experiment design for 3 courses “Solubility and induction time in nucleation”, “Physicochemical properties of drugs” and “Crystallization and Thermodynamics” at Strathclyde university, KTH and Imperial College

2017 2016-2017 2013-2015

Analytical and Modeling Skills  

 

Biotech skills: Sodium Dodecyl Sulfate (SDS Page), Hanging/sitting drop, High Throughput Screening (Mosquito), automated protein crystal optimizations (Dragonfly) Analytical skills: PUV-Vis Spectrophotometer (Nanodrop), X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Confocal Raman Microscopy (CRM), Differential Scanning Calorimetry (DSC), Thermal Gravimetric Analysis (TGA), Ultraviolet Spectrophotometer (UV), Liquid chromatography–mass spectrometry (LC-MS), Polarized Fourier-Transform Infrared Spectroscopy (FTIR) PAT skills: Focused Beam Reflectance Measurement (FBRM), Particle Vision Microscope (PVM), In-situ IR & Raman IT Skill: Matlab, OriginLab, g-Crystal(g-Proms), Material Studio

Presentations and Proceedings 1. 2. 3. 4. 5. 6. 7. 8. 9.

Yang, H.; Heng, J.; (2017) Poster presentation, Seeding and Continuous crystallization of Antibody Cd20. 253rd ACS National Meeting & Exposition, San Francisco, USA Yang, H.; Heng, J.; (2016) Oral presentation, Protein Crystallization, International Conference of Chemical Engineering and Industrial Biotechnology, Melaka, Malaysia Yang, H.; (2016) Invited oral presentation, Nucleation and Crystallization of Butyl Paraben, Tianjin University of Technology, Tianjin, China Yang, H.; Florence, A., (2016) Poster presentation, Nucleation, shear rate and size distribution of cluster, British Association for Crystal Growth, Leeds, UK Yang, H.; Florence, A., (2016) Oral presentation, Relation of Shear rate and Nucleation, Asian Crystallization Technology Symposium 2016, Tianjin, China Yang, H.; (2015) Invited oral presentation, Understanding crystallization of butyl paraben from thermodynamics to kinetics, GSK, Stevenage, UK Yang, H.; Florence, A., (2015) Poster presentation, Shear rate and Nucleation in oscillation fluid crystallizer, European Conference on Crystal Growth, Bologna, Italy Yang, H.; H. ter Horst; J Florence, A., (2015) Poster presentation, Metastable zone width with complex cooling profiles, CMAC open day, Glasgow, UK Yang, H.; Florence, A., (2015) Oral presentation, Relation between metastable zone width and induction time in nucleation, British Association for Crystal Growth, London, UK


10. Perciballi, F.; Yang, H.; Florence, A., (2014) Poster presentation (Best Poster Award, 2/50), Agglomeration of ibuprofen in ethanol and water liquid - liquid phase separation, British Association for Crystal Growth, Leeds, UK 11. Yang, H.; Florence, A.*, (2014) Shear rate and nucleation in continuous crystallizer, Proceedings of 19th International Symposium on Industrial Crystallization, Toulouse, France 12. Yang, H.; Rasmuson Å., (2011) Poster presentation, Nucleation of butyl paraben, propyl paraben and ethyl paraben in ethanol, ethyl acetate and acetone, British Association for Crystal Growth, University College London, London, UK 13. Yang, H.; Svärd, M.; Rasmuson Å.*, (2012) Interaction of parabens and solvents molecules in crystallization, Proceedings of 10th International Workshop on Crystal Growth of Organic Materials, University of Limerick, Limerick, Ireland 14. Yang, H.; Rasmuson Å.*, (2011) Crystallization of butyl paraben in mixtures of water and ethanol, Proceedings of 18th the International Symposium on Industry Crystallization, ETH, Zurich, Switzerland 15. Yang, H.; Rasmuson Å.*, (2010) Nucleation and crystallization of butyl paraben in liquid-liquid phases, Proceedings of 9th International Workshop on Crystal Growth of Organic Materials, Nanyang Technological University, Singapore



Dr. Huaiyu Yang Curriculum Vitae - Imperial College London

Dr. Huaiyu Yang Chemical Engineering Department, Loughborough University, LE11 3UE, UK, Mobile: +44 (0) 770 9686 684 E-mail: [email protected], Persona...

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